So here's how the weight-loss drug wars are playing out on a Monday: Eli Lilly and Company (LLY) shares are climbing, and it's not because of some earth-shattering news from Lilly itself. It's because Novo Nordisk A/S (NVO), its main rival in the obesity treatment arena, just had a bit of a stumble in a clinical trial. When one giant trips, the other tends to get a little boost.
The broader market was basically flat, but healthcare was up a bit. And Lilly, it seems, decided to go along for that ride with a little extra spring in its step, thanks to its competitor's news.
When a Trial "Miss" is Your Gain
Novo Nordisk's stock hit a 52-week low. The reason? Results from its REDEFINE 4 trial. The company was testing its weight-loss drug candidate, CagriSema, head-to-head against Eli Lilly's already-approved drug, tirzepatide (sold under the brands Zepbound and Mounjaro).
The goal was to show that CagriSema was at least as good—what's called "non-inferior"—as Lilly's drug. It wasn't. After 84 weeks, patients on CagriSema lost 20.2% of their body weight. Not bad, right? But patients on Lilly's tirzepatide lost 23.6%. That gap was enough for the trial to officially miss its mark on non-inferiority.
The trial had 809 subjects, and while CagriSema showed a safe profile, the results just didn't meet expectations. So now Novo Nordisk is looking ahead, pinning some hopes on its REDEFINE 11 trial, with results expected in the first half of 2027, which is supposed to really show what CagriSema can do.
In the meantime, the market's reaction was pretty clear: one company's disappointment is another's opportunity.












