Tuesday delivered a split personality for U.S. markets. The Dow Jones index slid around 250 points, but that didn't stop a parade of individual stocks from posting impressive gains. If you were watching the right names, it was actually a pretty good day.

Leading the charge was Moderna Inc. (MRNA), which jumped sharply after the biotech company delivered some encouraging updates at the 44th Annual J.P. Morgan Healthcare Conference. You know, the annual gathering where healthcare executives fly to San Francisco and investors try to figure out which companies are actually making money.

Moderna's news was legitimately solid. The company now expects 2025 revenue of approximately $1.9 billion, which comes in $100 million above the midpoint it previously communicated during its third-quarter earnings call. Even better, Moderna improved its 2025 expected GAAP operating expenses by $200 million and increased its projected year-end cash balance to approximately $8.1 billion. When you're cutting costs and raising revenue guidance simultaneously, investors tend to notice.

Moderna shares jumped 12.8% to $38.20 on Tuesday.

Other Notable Gainers

But Moderna wasn't alone in posting eye-catching moves. Here's who else had a strong showing:

TryHard Holdings Ltd (THH) shares rocketed 69.3% to $39.11 after the company announced it has entered into a binding collaboration agreement with Carnegie Hill Capital Partners to establish a Hong Kong-based investment fund. As if that wasn't enough, the company also announced a $10 million share repurchase program. That's the kind of double-barreled announcement that gets traders' attention.

TTM Technologies Inc (TTMI) gained 20.2% to $93.59, though the company didn't announce any specific catalyst for the move.

Wheels Up Experience Inc (UP) rose 19.2% to $1.19 in Tuesday's session.

Kosmos Energy Ltd (KOS) gained 16.4% to $1.20 after the company announced plans on Monday for a $350 million Nordic bond offering. Energy investors seem comfortable with the financing move.

T1 Energy Inc (TE) rose 15.2% to $8.32.

Structure Therapeutics Inc (GPCR) gained 15% to $79.75, continuing its recent momentum in the biotech space.

Contineum Therapeutics Inc (CTNM) jumped 15% to $10.55, adding to the day's healthcare theme.

Canadian Solar Inc (CSIQ) gained 13.5% to $22.98. Canadian Solar announced the closing of an offering of $230 million in convertible senior notes due 2031, giving the solar company fresh capital for growth.

Posco Holdings Inc (PKX) gained 12.5% to $60.55 in Tuesday trading.

Warby Parker Inc (WRBY) rose 10.5% to $29.36 in reaction to reports suggesting that Meta may double its Ray-Ban glasses output due to strong demand. When the tech giant making smart glasses needs more inventory, the eyewear retailer apparently benefits by association.

Option Care Health Inc (OPCH) gained 10.2% to $35.33 after the company reported preliminary fourth-quarter and full-year 2025 financial results that evidently pleased investors.

Kennametal Inc (KMT) gained 8.4% to $33.32. Jefferies analyst Stephen Volkmann upgraded Kennametal from Hold to Buy and raised the price target from $28 to $40, giving the industrial stock a meaningful boost.

Intel Corp (INTC) rose 8% to $47.56 after KeyBanc upgraded the stock from Sector Weight to Overweight. The chip giant has been on a wild ride lately, and analyst upgrades seem to be helping stabilize sentiment.

Roblox Corp (RBLX) gained 8% to $82.93. Morgan Stanley analyst Matthew Cost maintained Roblox with an Overweight rating and lowered the price target from $170 to $155. Wait, the stock went up 8% on a price target cut? Welcome to the weird logic of Wall Street, where maintaining conviction matters more than the specific number.

Advanced Micro Devices Inc (AMD) jumped 6.6% to $221.30 after KeyBanc upgraded the stock from Sector Weight to Overweight. The chip designer joined Intel in getting some analyst love on Tuesday.

All in all, it was one of those days where the headline index number told you nothing about the action underneath. Sure, the Dow was down. But if you owned biotech, tech, or energy stocks with positive catalysts, you probably had a pretty good Tuesday.