U.S. stocks enjoyed a solid Friday session, with the Dow Jones index adding around 200 points as investors digested a busy week of earnings and corporate news. The upbeat market mood lifted a diverse collection of stocks, from cancer treatment developers to nuclear energy providers.

CG Oncology Leads Gainers on Accelerated Trial Timeline

Leading the pack was CG Oncology Inc. (CGON), which surged 21.8% to $51.05 after delivering welcome news to investors waiting on clinical trial results. The company announced an expedited timeline for the topline data readout now expected in the first half of 2026 for the Phase 3 PIVOT-006 clinical trial comparing adjuvant intravesical cretostimogene grenadenorepvec versus surveillance in patients with intermediate-risk non-muscle invasive bladder cancer. In plain English, they're moving faster than expected, which tends to make shareholders happy.

A Wild Day for Smaller Names

Rich Sparkle Holdings Ltd (ANPA) absolutely exploded, jumping 113.6% to $51.70. The catalyst was a $39 million offering of 3 million ordinary shares at $13 per share. The stock trading well above the offering price suggests investors saw the equity raise as an opportunity rather than dilution to fear.

NovaBay Pharmaceuticals Inc. (NBY) surged 34.4% to $12.81, though the company didn't announce specific news to explain the move. Sometimes the market moves in mysterious ways.

Quanterix Corp (QTRX) gained 29.3% to $8.42 after naming Everett Cunningham as President and CEO, effective January 19. Leadership changes can energize a stock, particularly when investors view the incoming executive as capable of driving growth.

Biotech Stocks Catch a Bid

The biotech sector had a strong showing Friday. MoonLake Immunotherapeutics (MLTX) gained 21.7% to $17.45 after receiving U.S. Food and Drug Administration feedback on Thursday regarding the clinical evidence strategy for Sonelokimab (SLK) in Hidradenitis Suppurativa (HS), based on the Type B meeting requested by MoonLake. Getting clarity from the FDA on your regulatory pathway is always valuable, even if it doesn't guarantee approval.

Enliven Therapeutics Inc (ELVN) gained 21.5% to $28.24 after the clinical-stage biopharmaceutical company shared encouraging initial data from the ongoing Phase 1b ENABLE trial of ELVN-001 in patients with chronic myeloid leukemia (CML) that is relapsed, refractory, or intolerant to available tyrosine kinase inhibitors (TKIs). Early-stage trial data always comes with caveats, but "encouraging" beats "disappointing" every time.

Allogene Therapeutics Inc (ALLO) gained 19.5% to $1.78, continuing its recovery from deeply depressed levels.

Nuclear Energy Gets the Meta Boost

The nuclear energy space had a standout day thanks to Meta's growing appetite for power. Vistra Corp (VST) gained 13.1% to $170.34 after entering into 20-year power purchase agreements to supply more than 2,600 megawatts of zero-carbon nuclear energy to support Meta's operations. That's a massive, long-term commitment that provides revenue visibility for two decades.

Oklo Inc (OKLO) rose 12.6% to $109.95 after announcing an agreement with Meta to advance plans for a 1.2 gigawatt power campus to support Meta's data centers. The artificial intelligence boom is creating unprecedented power demands, and tech giants are increasingly turning to nuclear energy to meet those needs with clean, reliable baseload power.

Tech and Real Estate Join the Rally

Aeva Technologies Inc (AEVA) surged 21.2% to $20.47 in what appeared to be momentum-driven trading without specific company news.

Applied Digital Corp (APLD) surged 11.8% to $35.72 after reporting a strong beat for the second quarter of fiscal 2026 and revealing it is in advanced talks with a new hyperscaler tenant, according to Needham. The data center buildout continues at a furious pace.

Real estate stocks got a lift from policy developments. Opendoor Technologies Inc (OPEN) rose 19.2% to $7.67 following a new proposal by President Donald Trump with big implications for the nation's housing market. Loandepot Inc (LDI) rose 20.1% to $2.93, likely benefiting from the same housing-related optimism.

More Notable Gainers

Liquidia Corp (LQDA) jumped 14% to $36.22 after announcing preliminary full-year 2025 YUTREPIA net sales and corporate update. Positive preliminary results can build momentum heading into official earnings releases.

ASP Isotopes Inc (ASPI) rose 19.7% to $7.71, continuing its volatile trading pattern.

AST SpaceMobile Inc (ASTS) gained 10% to $99.65 as the space-based cellular broadband provider maintained its upward trajectory.

SanDisk Corp (SNDK) gained 9.6% to $366.93, reflecting continued strength in the memory and storage sector.

Mirion Technologies Inc (MIR) rose 9.5% to $26.56, potentially benefiting from the broader interest in nuclear energy infrastructure.

TTM Technologies Inc (TTMI) gained 9.1% to $72.94, riding positive sentiment in the electronics manufacturing space.

SoundHound AI Inc (SOUN) rose 8.5% to $11.96 as AI-related stocks maintained their appeal.

Kratos Defense & Security Solutions Inc (KTOS) gained 8.3% to $112.64 after B. Riley Securities analyst Mike Crawford maintained Kratos Defense & Security with a Buy and raised the price target from $105 to $128. Analyst upgrades can provide a helpful tailwind, particularly when they come from respected firms.

All told, it was a solid day for risk-on trades across multiple sectors, with particular strength in biotech, nuclear energy, and technology infrastructure plays.