Monday was busy for Cathie Wood's Ark Invest, and if you're tracking where the famously forward-thinking investor is placing her bets, the answer is clear: artificial intelligence, particularly in healthcare and autonomous vehicles. The firm made substantial moves involving Tempus AI Inc. (TEM) and Kodiak AI Inc. (NGM: KDK), while simultaneously paring back positions in Roku Inc. (ROKU) and Shopify Inc. (SHOP).

Doubling Down on Tempus AI

The standout transaction was Ark's hefty purchase of Tempus AI shares. The firm scooped up 32,627 shares through the ARK Genomic Revolution ETF (ARKG) and another 195,999 shares via the ARK Innovation ETF (ARKK). With Tempus AI closing at $64.70, we're looking at roughly $14.8 million in total value. That's not a casual investment—it's a statement.

The timing is interesting too. Tempus AI has been generating serious buzz lately, with unusual options activity suggesting investors are feeling bullish about the company's prospects. For a firm like Ark, which has built its reputation on identifying disruptive technology early, this accumulation suggests Wood sees significant upside in how AI is transforming healthcare diagnostics and precision medicine.

Adding Kodiak AI to the Robotics Portfolio

Ark also picked up 53,302 shares of Kodiak AI for its ARK Autonomous Technology & Robotics ETF (ARKQ). At $10.40 per share, the purchase came to approximately $554,340. What makes this particularly noteworthy is Kodiak's backing from George Soros, lending some heavyweight credibility to the driverless truck company.

Kodiak operates in the autonomous trucking space, which aligns perfectly with Ark's thesis on innovative transportation technologies. As logistics companies hunt for ways to address driver shortages and improve efficiency, autonomous trucking has moved from science fiction to serious business opportunity. Ark clearly wants exposure to that trend.

Trimming Roku Despite Upgrade

On the selling side, Ark offloaded 109,254 Roku (ROKU) shares from ARKK. With the stock closing at $114.68, the transaction totaled approximately $12.5 million. This is a sizable reduction, especially considering Roku's recent performance and analyst sentiment.

Roku's third-quarter earnings, released back in October, actually beat expectations with net revenue of $1.211 billion—up 14% year over year and slightly above the Street consensus of $1.206 billion. More recently, Arete upgraded the stock from Neutral to Buy with a $132 price target, suggesting analysts see room for the streaming platform to run higher. Yet Ark is heading for the exit. Perhaps Wood sees better opportunities elsewhere, or maybe she's concerned about increased competition in the streaming wars.

Continuing the Shopify Exodus

Ark also reduced its Shopify (SHOP) position by selling 24,447 shares from ARKK. At $166.21 per share, the sale brought in roughly $4.06 million. This continues a pattern—Wood has been systematically trimming Shopify for weeks now.

Just last month, she sold $5.6 million worth of Shopify stock, even as the company rolled out its Winter 2026 Edition featuring expanded AI capabilities, improved checkout processes, and enhanced merchant tools. JPMorgan responded enthusiastically to those updates, saying they reinforced confidence in Shopify's long-term growth trajectory. The bank specifically highlighted deeper integration of Shopify's Sidekick AI assistant, which now includes proactive features designed to help small and midsize merchants scale more efficiently. Despite this bullish analyst take, Wood seems unconvinced—or at least sees better risk-adjusted returns elsewhere in her portfolio.

Other Notable Moves

Beyond the headline trades, Ark made several other adjustments:

• Sold 3,558 shares of Natera Inc. (NTRA) from ARKG.
• Sold 7,228 shares of Guardant Health Inc. (GH) from ARKG.
• Bought 47,587 shares of Personalis Inc. (PSNL) for ARKG.

These genomics-focused trades suggest some rebalancing within the healthcare portfolio, with Ark rotating from established players into smaller positions that might offer more upside potential.

What the Data Says

According to market rankings, Tempus AI (TEM) currently sits in the 86th percentile for momentum—a metric that tracks price strength and trend continuation. That kind of momentum reading typically indicates strong buying pressure and positive investor sentiment, which certainly aligns with Ark's decision to load up on shares.

As always with Cathie Wood's trades, the question isn't just what she's buying and selling—it's what these moves signal about where she sees the future heading. Right now, that future appears to involve significantly more AI-powered healthcare and autonomous technology, and somewhat less streaming entertainment and e-commerce platforms.