GH Research PLC (GHRS) is having a morning. Shares rocketed 18.1% to $15.64 in premarket trading after the biotechnology company said it would provide an update on its FDA IND status and Phase 3 program for GH001, its experimental treatment for treatment-resistant depression. When a company working on mental health therapies promises news about FDA interactions, investors tend to pay attention.
But GH Research wasn't alone in making waves before the opening bell. Here's a look at the other notable movers in premarket trading.
The Big Gainers
MKDWELL Tech Inc (MKDW) absolutely exploded higher, surging 61.2% to $0.27. The catalyst? The company agreed to repurchase 34,580,000 ordinary shares at $0.203 per share, totaling $7 million in buybacks. That's a substantial commitment for a penny stock.
Regencell Bioscience Holdings Ltd (RGC) gained 52% to $31.21 in premarket action, bouncing back after a 2% decline on Friday. No specific news drove the move, making this one to watch for momentum traders.
Datavault AI Inc (DVLT) continued its hot streak, climbing 26.7% to $1.28 after already jumping 55% on Friday. Whatever's fueling this rally, traders clearly aren't ready to let go yet.
Sidus Space Inc (SIDU) added another 21.9% to $5.28, extending Friday's impressive 38% gain. The space technology company is riding serious momentum.
Kazia Therapeutics Ltd (KZIA) bounced 21.7% to $6.08 after getting hammered for a 27% loss on Friday. Classic volatile biotech behavior right there.
Context Therapeutics Inc (CNTX) gained 18.7% to $1.84, building on Friday's 5% advance.
Hyperscale Data Inc (GPUS) rose 18.6% to $0.32, continuing its momentum after a 49% surge on Friday.
PBF Energy Inc (PBF) climbed 16.7% to $33.30 on actual news: the refining company issued an update on its Martinez refinery operations and released 2026 annual guidance. When energy companies offer forward guidance, it gives investors something concrete to work with.
Bioatla Inc (BCAB) rounded out the gainers with a 16.1% jump to $0.62, recovering from Friday's 5% dip.
The Decliners
Salarius Pharmaceuticals Inc (SLRX) fell 21.8% to $0.51 in premarket trading, leading the losers.
Gain Therapeutics Inc (GANX) dropped 21.4% to $2.50, continuing the biotech sector's wild swings.
SBC Medical Group Holdings Inc (SBC) declined 18.9% to $3.51 without any obvious catalyst.
Polyrizon Ltd (PLRZ) gave back some gains, falling 11.7% to $11.24 after Friday's 50% explosion. Profit-taking seems like the obvious explanation here.
ChowChow Cloud International HLDG Ltd (CHOW) dipped 10.3% to $0.71 despite solid fundamentals. The company had jumped 30% on Friday after reporting year-over-year increases in H1 2025 revenue and net income, but traders are apparently locking in gains.
Lavoro Ltd (LVRO) shares fell 9.1% to $1.00 after an absolutely massive 144% rally on Friday. When a stock more than doubles in a day, some pullback is practically guaranteed.
Vicarious Surgical Inc (RBOT) declined 7.9% to $2.32 after a 16% gain on Friday.
Theravance Biopharma Inc (TBPH) dipped 6% to $17.07, extending Friday's 3% decline.
Comcast Corp (CMCSA) tumbled 4.6% to $28.18 in premarket trading. When a mega-cap stock like Comcast drops nearly 5% before the bell, it's worth watching for broader market implications.
Equinor ASA (EQNR) fell 3.6% to $23.66 after gaining 4% on Friday, rounding out the notable decliners.
The premarket session is shaping up as another volatile day, with biotechs and small caps leading the action in both directions. Whether these moves hold through the regular session is anyone's guess, but it's clear traders are positioned for some serious swings.
